Submitted by kej2006 on June 6, 2018 - 4:13pm
| Title | Discordant Findings on 18F-NaF and 99mTc-HDP Bone Scans in a Patient With ATTR Cardiac Amyloidosis. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Ng QKT, Sethi P, Saunders TA, Pampaloni MHernandez, Flavell RR |
| Journal | Clin Nucl Med |
| Volume | 43 |
| Issue | 3 |
| Pagination | e89-e92 |
| Date Published | 2018 Mar |
| ISSN | 1536-0229 |
| Keywords | Aged, Amyloidosis, Bone and Bones, Diphosphonates, Fluorine Radioisotopes, Humans, Male, Organotechnetium Compounds, Positron Emission Tomography Computed Tomography, Prealbumin, Sodium Fluoride |
| Abstract | Cardiac amyloidosis is an important cause of restrictive cardiomyopathy and congestive heart failure. Bone scintigraphy with [Tc]hydroxymethylene diphosphonate (Tc-HDP) and [F]sodium fluoride (F-NaF) have been investigated in the noninvasive diagnosis of transthyretin (ATTR)-related cardiac amyloidosis. We present a case of a 76-year-old man with metastatic prostate cancer who underwent Tc-HDP bone scintigraphy with an incidental finding of diffuse left ventricular abnormal uptake suggesting ATTR cardiac amyloidosis. Review of previous imaging showed a negative F-NaF PET/CT study. This example suggests that the mechanism of uptake of Tc-HDP and F-NaF may differ in patients with ATTR cardiac amyloidosis. |
| DOI | 10.1097/RLU.0000000000001933 |
| Alternate Journal | Clin Nucl Med |
| PubMed ID | 29261619 |