Casticin from Vitex species: a short review on its anticancer and anti-inflammatory properties.

TitleCasticin from Vitex species: a short review on its anticancer and anti-inflammatory properties.
Publication TypeJournal Article
Year of Publication2018
AuthorsChan EWei Chiang, Wong SKuin, Chan HTuck
JournalJ Integr Med
Volume16
Issue3
Pagination147-152
Date Published2018 May
ISSN2095-4964
Abstract

This short review provides an update of the anticancer and anti-inflammatory properties of casticin from Vitex species. Casticin is a polymethylflavone with three rings, an orthocatechol moiety, a double bond, two hydroxyl groups and four methoxyl groups. Casticin has been isolated from various tissues of plants in the Vitex genus: fruits and leaves of V. trifolia, aerial parts and seeds of V. agnus-castus and leaves of V. negundo. Studies have reported the antiproliferative and apoptotic activities of casticin from Vitex species. The compound is effective against many cancer cell lines via different molecular mechanisms. Studies have also affirmed the anti-inflammatory properties of casticin, with several molecular mechanisms identified. Other pharmacological properties include anti-asthmatic, tracheospasmolytic, analgesic, antihyperprolactinemia, immunomodulatory, opioidergic, oestrogenic, anti-angiogenic, antiglioma, lung injury protection, rheumatoid arthritis amelioration and liver fibrosis attenuation activities. Clinical trials and commercial use of the casticin-rich fruit extract of V. agnus-castus among women with premenstrual syndrome were briefly discussed.

DOI10.1016/j.joim.2018.03.001
Alternate JournalJ Integr Med
PubMed ID29559215

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