Submitted by kej2006 on June 6, 2018 - 4:13pm
| Title | Activation of RhoA, Smad2, c-Src, PKC-βII/δ and JNK in atopic dermatitis. |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Lu J, Yin R, Fu Z, Lee VM, Nelson JStuart, Tan W |
| Journal | Australas J Dermatol |
| Date Published | 2018 Mar 02 |
| ISSN | 1440-0960 |
| Abstract | Atopic dermatitis is a multifactorial skin disease characterised by chronic and relapsing inflammation whose pathogenesis is incompletely understood. We found that the expression of TGFβR1 and the activation of SMAD2, RhoA, JNK, PKC-βII/δ and c-Src were upregulated in the infiltrated inflammatory cells, fibroblasts and vasculatures in the dermis and epidermis. In addition, increases in the expression of TGFβR1 and phosphorylation levels of JNK and c-Src were positively correlated with the inflammatory progression of atopic dermatitis severity. |
| DOI | 10.1111/ajd.12801 |
| Alternate Journal | Australas. J. Dermatol. |
| PubMed ID | 29498756 |
| Grant List | K01 AR063766 / AR / NIAMS NIH HHS / United States |