Title | γ-Hydroxybutyric acid-induced electrographic seizures. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Cheung J, Lucey BP, Duntley SP, Darken RS |
Journal | J Clin Sleep Med |
Volume | 10 |
Issue | 7 |
Pagination | 811-2 |
Date Published | 2014 Jul 15 |
ISSN | 1550-9397 |
Keywords | Adult, Anesthetics, Electroencephalography, Epilepsy, Absence, Humans, Hydroxybutyrates, Male, Sodium Oxybate |
Abstract | We describe a case of absence-like electrographic seizures during NREM sleep in a patient who was taking sodium oxybate, a sodium salt of γ-hydroxybutyric acid (GHB). An overnight full montage electroencephalography (EEG) study revealed numerous frontally predominant rhythmic 1.5-2 Hz sharp waves and spike-wave activity during stage N2 and N3 sleep at the peak dose time for sodium oxybate, resembling atypical absence-like electrographic seizures. The patient was later weaned off sodium oxybate, and a repeat study did not show any such electrographic seizures. Absence-like seizures induced by GHB had previously been described in experimental animal models. We present the first reported human case of absence-like electrographic seizure associated with sodium oxybate. |
DOI | 10.5664/jcsm.3882 |
Alternate Journal | J Clin Sleep Med |
PubMed ID | 25024661 |
PubMed Central ID | PMC4067447 |
Submitted by kej2006 on June 6, 2018 - 4:11pm