Submitted by bel2021 on April 19, 2022 - 11:39am
| Title | Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | McGary LHF, Vardhana SA |
| Journal | Cancer Discov |
| Volume | 12 |
| Issue | 4 |
| Pagination | 892-894 |
| Date Published | 2022 Apr 01 |
| ISSN | 2159-8290 |
| Keywords | COVID-19, Humans, Membrane Glycoproteins, SARS-CoV-2, Spike Glycoprotein, Coronavirus, T-Lymphocytes, Viral Envelope Proteins |
| Abstract | SUMMARY: Fahrner and colleagues investigated the immune response of patients with cancer and cancer-free individuals to SARS-CoV-2 and found that a propensity toward an IL5-predominant Th2/Tc2 response was predictive of susceptibility to infection. The results of this study also suggest that a cellular response against the Spike 1 protein receptor binding domain (S1-RBD) region of the SARS-CoV-2 proteome contributes to protection and that mutations in this region may drive viral evolution and immune escape. See related article by Fahrner et al., p. 958 (8). |
| DOI | 10.1158/2159-8290.CD-22-0080 |
| Alternate Journal | Cancer Discov |
| PubMed ID | 35373282 |