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Vive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection.

TitleVive la Résistance: T-cell Immunity in the Protection against SARS-CoV-2 Infection.
Publication TypeJournal Article
Year of Publication2022
AuthorsMcGary LHF, Vardhana SA
JournalCancer Discov
Volume12
Issue4
Pagination892-894
Date Published2022 Apr 01
ISSN2159-8290
KeywordsCOVID-19, Humans, Membrane Glycoproteins, SARS-CoV-2, Spike Glycoprotein, Coronavirus, T-Lymphocytes, Viral Envelope Proteins
Abstract

SUMMARY: Fahrner and colleagues investigated the immune response of patients with cancer and cancer-free individuals to SARS-CoV-2 and found that a propensity toward an IL5-predominant Th2/Tc2 response was predictive of susceptibility to infection. The results of this study also suggest that a cellular response against the Spike 1 protein receptor binding domain (S1-RBD) region of the SARS-CoV-2 proteome contributes to protection and that mutations in this region may drive viral evolution and immune escape. See related article by Fahrner et al., p. 958 (8).

DOI10.1158/2159-8290.CD-22-0080
Alternate JournalCancer Discov
PubMed ID35373282

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