| Title | Risk of Zika microcephaly correlates with features of maternal antibodies. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Robbiani DF, Olsen PC, Costa F, Wang Q, Oliveira TY, Nery N, Aromolaran A, Rosário MS do, Sacramento GA, Cruz JS, Khouri R, Wunder EA, Mattos A, Freitas Bde Paula, Sarno M, Archanjo G, Daltro D, Carvalho GBS, Pimentel K, de Siqueira IC, de Almeida JRM, Henriques DF, Lima JA, Vasconcelos PFC, Schaefer-Babajew D, Azzopardi SA, Bozzacco L, Gazumyan A, Belfort R, Alcântara AP, Carvalho G, Moreira L, Araujo K, Reis MG, Keesler RI, Coffey LL, Tisoncik-Go J, Gale M, Rajagopal L, Waldorf KMAdams, Dudley DM, Simmons HA, Mejia A, O'Connor DH, Steinbach RJ, Haese N, Smith J, Lewis A, Colgin L, Roberts V, Frias A, Kelleher M, Hirsch A, Streblow DN, Rice CM, MacDonald MR, de Almeida ARP, Van Rompay KKA, Ko AI, Nussenzweig MC |
| Journal | J Exp Med |
| Volume | 216 |
| Issue | 10 |
| Pagination | 2302-2315 |
| Date Published | 2019 Oct 07 |
| ISSN | 1540-9538 |
| Abstract | Zika virus (ZIKV) infection during pregnancy causes congenital abnormalities, including microcephaly. However, rates vary widely, and the contributing risk factors remain unclear. We examined the serum antibody response to ZIKV and other flaviviruses in Brazilian women giving birth during the 2015-2016 outbreak. Infected pregnancies with intermediate or higher ZIKV antibody enhancement titers were at increased risk to give birth to microcephalic infants compared with those with lower titers (P < 0.0001). Similarly, analysis of ZIKV-infected pregnant macaques revealed that fetal brain damage was more frequent in mothers with higher enhancement titers. Thus, features of the maternal antibodies are associated with and may contribute to the genesis of ZIKV-associated microcephaly. |
| DOI | 10.1084/jem.20191061 |
| Alternate Journal | J. Exp. Med. |
| PubMed ID | 31413072 |
| PubMed Central ID | PMC6781003 |
| Grant List | P51 OD011092 / OD / NIH HHS / United States U19 AI083019 / AI / NIAID NIH HHS / United States P51 OD010425 / OD / NIH HHS / United States R01 AI133976 / AI / NIAID NIH HHS / United States R25 TW009338 / TW / FIC NIH HHS / United States R01 AI100989 / AI / NIAID NIH HHS / United States R01 TW009504 / TW / FIC NIH HHS / United States R01 AI121207 / AI / NIAID NIH HHS / United States R01 AI104002 / AI / NIAID NIH HHS / United States P51 OD011106 / OD / NIH HHS / United States |
Submitted by bel2021 on December 2, 2019 - 10:01am