Title | Representation of visual landmarks in retrosplenial cortex. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Fischer LF, Soto-Albors RMojica, Buck F, Harnett MT |
Journal | Elife |
Volume | 9 |
Date Published | 2020 Mar 10 |
ISSN | 2050-084X |
Abstract | The process by which visual information is incorporated into the brain's spatial framework to represent landmarks is poorly understood. Studies in humans and rodents suggest that retrosplenial cortex (RSC) plays a key role in these computations. We developed an RSC-dependent behavioral task in which head-fixed mice learned the spatial relationship between visual landmark cues and hidden reward locations. Two-photon imaging revealed that these cues served as dominant reference points for most task-active neurons and anchored the spatial code in RSC. This encoding was more robust after task acquisition. Decoupling the virtual environment from mouse behavior degraded spatial representations and provided evidence that supralinear integration of visual and motor inputs contributes to landmark encoding. V1 axons recorded in RSC were less modulated by task engagement but showed surprisingly similar spatial tuning. Our data indicate that landmark representations in RSC are the result of local integration of visual, motor, and spatial information. |
DOI | 10.7554/eLife.51458 |
Alternate Journal | Elife |
PubMed ID | 32154781 |
PubMed Central ID | PMC7064342 |
Grant List | RO1NS106031 / NH / NIH HHS / United States |
Submitted by bel2021 on March 24, 2020 - 11:02am