| Title | A panoramic view of cell population dynamics in mammalian aging. |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Zhang Z, Schaefer C, Jiang W, Lu Z, Lee J, Sziraki A, Abdulraouf A, Wick B, Haeussler M, Li Z, Molla G, Satija R, Zhou W, Cao J |
| Journal | Science |
| Volume | 387 |
| Issue | 6731 |
| Pagination | eadn3949 |
| Date Published | 2025 Jan 17 |
| ISSN | 1095-9203 |
| Keywords | Aging, Animals, Cell Lineage, Cellular Senescence, Female, Gene Expression Profiling, Immune System, Longevity, Lymphocytes, Male, Mice, Organ Specificity, Single-Cell Analysis, Transcriptome |
| Abstract | To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling >20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes. This comprehensive dataset reveals >3000 different cellular states and >200 aging-associated cell populations. Our panoramic analysis uncovered organ-, lineage-, and sex-specific shifts in cellular dynamics during life-span progression. Moreover, we identify both systematic and organ-specific alterations in immune cell populations associated with aging. We further explored the regulatory roles of the immune system on aging and pinpointed specific age-related cell population expansions that are lymphocyte dependent. Our "cell-omics" strategy enhances comprehension of cellular aging and lays the groundwork for exploring the complex cellular regulatory networks in aging and aging-associated diseases. |
| DOI | 10.1126/science.adn3949 |
| Alternate Journal | Science |
| PubMed ID | 39607904 |
| Grant List | RM1 HG011014 / HG / NHGRI NIH HHS / United States |
Submitted by est4003 on March 6, 2025 - 10:52am