Submitted by bel2021 on December 2, 2019 - 10:05am
Title | Lessons learned from the development of a hidradenitis suppurativa xenograft mouse model. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Quartey QQ, Miller RJ, Pinsker BL, Okoh UJ, Shipman WD, George BA, Nwizu CC, Barnes LA, Kerns ML, Caffrey JA, Aliu O, Brown ID, Succaria F, Maynard JP, Herbert AS, Kang S, Miller LS, Okoye GA, Byrd AS |
Journal | Clin Exp Dermatol |
Date Published | 2019 Jul 19 |
ISSN | 1365-2230 |
Abstract | Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an animal model for experimental studies. We developed an HS xenograft mouse model using human HS lesions grafted onto immunocompromised mice. Although the model had its limitations, several informative lessons were learned, which may contribute to future attempts at an HS animal model. |
DOI | 10.1111/ced.14054 |
Alternate Journal | Clin. Exp. Dermatol. |
PubMed ID | 31322280 |
Grant List | Johns Hopkins Ethnic Skin Fellowship / / Valeant Pharmaceuticals International / / / Johns Hopkins Physician Scientist Training Program (PSTP) / / / Danby Hidradenitis Suppurativa Foundation Research Grant / |