Title | An EBV+ lymphoepithelioma-like cholangiocarcinoma in a young woman with chronic hepatitis B. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Gearty SV, Jurdi AAl, Pittman ME, Gupta R |
Journal | BMJ Case Rep |
Volume | 12 |
Issue | 7 |
Date Published | 2019 Jul 08 |
ISSN | 1757-790X |
Abstract | Epstein-Barr virus (EBV) is implicated in the tumorigenesis of a variety of malignancies, including Burkitt's lymphoma, Hodgkin's disease and nasopharyngeal carcinoma (NPC). EBV+ lymphoepithelioma-like cholangiocarcinoma (LELCC) is a rare type of intrahepatic cholangiocarcinoma with a distinct pathology and poorly understood treatment options. Morphologically, this neoplasm resembles undifferentiated NPC, a commonly EBV+ tumour with a prominent lymphoid infiltrate. Almost all of the current literature regarding LELCC describes early stage tumours that are treated surgically and achieve good outcomes. In contrast, this report documents a late stage LELCC treated unsuccessfully with systemic chemotherapy. |
DOI | 10.1136/bcr-2019-229520 |
Alternate Journal | BMJ Case Rep |
PubMed ID | 31289161 |
PubMed Central ID | PMC6615824 |
Grant List | T32 GM007739 / GM / NIGMS NIH HHS / United States |
Submitted by bel2021 on December 2, 2019 - 10:06am