In-Depth Analysis of the Hidradenitis Suppurativa Serum Proteome Identifies Distinct Inflammatory Subtypes.

TitleIn-Depth Analysis of the Hidradenitis Suppurativa Serum Proteome Identifies Distinct Inflammatory Subtypes.
Publication TypeJournal Article
Year of Publication2021
AuthorsNavrazhina K, Garcet S, Gonzalez J, Grand D, Frew JW, Krueger JG
JournalJ Invest Dermatol
Date Published2021 Mar 22
ISSN1523-1747
Abstract

Hidradenitis Suppurativa (HS) is a chronic inflammatory dermatosis with presentations ranging from painful nodules and abscesses to draining tunnels. Using an unbiased proteomics approach, we assessed 368 cardiovascular, cardiometabolic and inflammation-related biomarkers in serum of moderate to severe HS patients. HS serum clustered separately from healthy controls and had an up-regulation of neutrophil-related markers (Cathepsin D, IL-17A, CXCL1). Patients with histologically diagnosed dermal tunnels had higher serum Lipocalin-2 (LCN2) levels compared to those without tunnels. Consistent with this, patients with tunnels had a more neutrophilic-rich serum signature, marked by Cathepsin D, IL-17A, IL-17D, and MMP-2 alterations. There was a significant serum-skin correlation between proteins in the serum and the corresponding mRNA levels in skin biopsies, with healthy-appearing perilesional skin demonstrating a significant correlation with neutrophil-related proteins in the serum. Granulocyte-colony stimulating factor (G-CSF, CFS3) mRNA levels in lesional skin significantly correlated with neutrophil-related proteins in the serum, suggesting that CFS3 in the skin may be a driver of neutrophilic inflammation. Clinical parameters significantly correlated with levels of LCN2 and IL-17A in the serum. Using an unbiased, large-scale proteomic approach, we demonstrate that HS is a systemic neutrophilic dermatosis, with a specific molecular signature associated with the presence of dermal tunnels.

DOI10.1016/j.jid.2021.02.742
Alternate JournalJ Invest Dermatol
PubMed ID33766512

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