Spatial and temporal coordination of antiviral responses by group 1 ILCs.

TitleSpatial and temporal coordination of antiviral responses by group 1 ILCs.
Publication TypeJournal Article
Year of Publication2018
AuthorsAdams NM, Sun JC
JournalImmunol Rev
Volume286
Issue1
Pagination23-36
Date Published2018 11
ISSN1600-065X
KeywordsAnimals, Cell Differentiation, Cytokines, Homeostasis, Humans, Immunity, Innate, Killer Cells, Natural, Lymphocytes, Th1 Cells, Virus Diseases
Abstract

Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context-dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic perturbations. With a focus on viral infection, this review highlights the organization and regulation of spatially and temporally distinct waves of NK cell and ILC1 responses that collectively serve to achieve optimal viral control.

DOI10.1111/imr.12710
Alternate JournalImmunol. Rev.
PubMed ID30294970
PubMed Central IDPMC6178831
Grant ListT32GM007739 / GM / NIGMS NIH HHS / United States
R01 AI100874 / AI / NIAID NIH HHS / United States
P30 CA008748 / CA / NCI NIH HHS / United States
P30CA008748 / / National Institute of Allergy and Infectious Diseases / International
F30 AI136239 / / National Institute of Allergy and Infectious Diseases / International
T32 GM007739 / GM / NIGMS NIH HHS / United States
F30 AI136239 / AI / NIAID NIH HHS / United States
R01 AI130043 / AI / NIAID NIH HHS / United States

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