Submitted by api_import on December 18, 2018 - 11:39am
Title | Spatial and temporal coordination of antiviral responses by group 1 ILCs. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Adams NM, Sun JC |
Journal | Immunol Rev |
Volume | 286 |
Issue | 1 |
Pagination | 23-36 |
Date Published | 2018 11 |
ISSN | 1600-065X |
Keywords | Animals, Cell Differentiation, Cytokines, Homeostasis, Humans, Immunity, Innate, Killer Cells, Natural, Lymphocytes, Th1 Cells, Virus Diseases |
Abstract | Group 1 innate lymphocytes consist of a phenotypically, spatially, and functionally heterogeneous population of NK cells and ILC1s that are engaged during pathogen invasion. We are only beginning to understand the context-dependent roles that different subsets of group 1 innate lymphocytes play during homeostatic perturbations. With a focus on viral infection, this review highlights the organization and regulation of spatially and temporally distinct waves of NK cell and ILC1 responses that collectively serve to achieve optimal viral control. |
DOI | 10.1111/imr.12710 |
Alternate Journal | Immunol. Rev. |
PubMed ID | 30294970 |
PubMed Central ID | PMC6178831 |
Grant List | T32GM007739 / GM / NIGMS NIH HHS / United States R01 AI100874 / AI / NIAID NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States P30CA008748 / / National Institute of Allergy and Infectious Diseases / International F30 AI136239 / / National Institute of Allergy and Infectious Diseases / International T32 GM007739 / GM / NIGMS NIH HHS / United States F30 AI136239 / AI / NIAID NIH HHS / United States R01 AI130043 / AI / NIAID NIH HHS / United States |